Search results for " cytoreductive surgery"

showing 3 items of 3 documents

The role of surgery in platinum-resistant ovarian cancer: A call to the scientific community.

2021

Abstract In the last decade, a growing attention has been focused on identifying effective therapeutic strategies also in the orphan clinical setting of women with platinum-resistant disease. In this context, secondary cytoreductive surgery (SCS) remains a potential approach only in women with platinum sensitive relapse, but experimental data have been published supporting the role of SCS also in patients with platinum-resistant recurrence. In particular, surgery is emerging as a potential option in specific subgroups of women, such as those patients with low-grade serous histology, or low-volume relapse with disease located in the so-called pharmacological sanctuaries. Furthermore, contras…

0301 basic medicineCancer Researchmedicine.medical_specialtymedicine.medical_treatmentContext (language use)Antineoplastic AgentsPlatinum CompoundsDiseaseHyperthermic Intraperitoneal ChemotherapyCarcinoma Ovarian Epithelial03 medical and health sciences0302 clinical medicineMedicineAnimalsHumansIn patientPlatinum resistantChemotherapybusiness.industryCytoreduction Surgical Proceduresmedicine.diseaseCombined Modality TherapySurgerySerous fluid030104 developmental biologyDrug Resistance Neoplasm030220 oncology & carcinogenesisPlatinum sensitiveFemaleNeoplasm Recurrence LocalbusinessOvarian cancerBiological features Minimally invasive surgery Personalized treatment Platinum resistant Recurrent ovarian cancer Secondary cytoreductive surgerySeminars in cancer biology
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IMPROVEMENT IN REDOX HOMEOSTASIS AFTER CYTOREDUCTIVE SURGERY IN COLORECTAL ADENOCARCINOMA

2021

Colorectal cancer (CRC) as one the most common cancer type is associated with oxidative stress. Surgery is the only curative modality for early-stage CRC. The aim of this study was to evaluate the oxidative damage biomarkers as well as enzymatic and nonenzymatic antioxidants in patients with CRC before and after tumor resection and in healthy controls. 60 patients with stage I/II colorectal adenocarcinoma and 43 healthy controls were recruited in this study. We measured plasma levels of oxidative damage biomarkers, including advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), malondialdehyde (MDA), and oxidized low-density lipoprotein (ox-LDL) at baseline and…

Glycation End Products AdvancedMale0301 basic medicineAgingAntioxidantColorectal cancermedicine.medical_treatmentmedicine.disease_causeBiochemistryGastroenterologychemistry.chemical_compoundPostoperative Complications0302 clinical medicineMalondialdehydeHomeostasischemistry.chemical_classificationbiologyGlutathione peroxidaseCytoreduction Surgical ProceduresGeneral MedicineMiddle AgedCatalaseMalondialdehydecolorectal cancer colorectal surgery cytoreductive surgery redox homeostasisLipoproteins LDLCatalase030220 oncology & carcinogenesisFemaleColorectal NeoplasmsResearch ArticleAdultmedicine.medical_specialtyArticle SubjectAdenocarcinomaSuperoxide dismutase03 medical and health sciencesInternal medicinemedicineHumansAgedGlutathione PeroxidaseQH573-671business.industryCell Biologymedicine.diseaseOxidative Stress030104 developmental biologychemistrybiology.proteinCytologybusinessOxidative stressLipoprotein
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Concordance of Radiological, Laparoscopic and Laparotomic Scoring to Predict Complete Cytoreduction in Women with Advanced Ovarian Cancer

2023

Objective: To identify the best method among the radiologic, laparoscopic and laparotomic scoring assessment to predict the outcomes of cytoreductive surgery in patients with advanced ovarian cancer (AOC). Methods: Patients with AOC who underwent pre-operative computed tomography (CT) scan, laparoscopic evaluation, and cytoreductive surgery between August 2016 and February 2021 were retrospectively reviewed. Predictive Index (PI) score and Peritoneal Cancer Index (PCI) scores were used to estimate the tumor load and predict the residual disease in the primary debulking surgery (PDS) and interval debulking surgery (IDS) after neoadjuvant chemotherapy (NACT) groups. Concordance percentages we…

Predictive index scoreCancer ResearchOncologyOvarian cancerPrediction modelCytoreductive surgeryPrimary debulking surgery.Interval debulking surgeryNeoadjuvant chemotherapyPeritoneal cancer index scoreSettore MED/40 - Ginecologia E Ostetriciaovarian cancer; cytoreductive surgery; prediction model; predictive index score; peritoneal cancer index score; primary debulking surgery; interval debulking surgery; neoadjuvant chemotherapyCancers
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